The present study was taken up to find out occupational stress amongst teachers working in DIET colleges of united Andhra Pradesh. The study also aimed to find out influence of age and region on occupational stress. Descriptive survey method was adopted for the study. A sample of 480 college teachers from different DIET colleges were selected by stratified random sampling technique. The “Occupational Stress Index” was developed and standardized by Srivastava, A.K. and Singh, A.P. (1981) was adopted and used for data collection. The data were analysed by using statistical techniques viz., Mean, SD and t-test. The results revealed that there is a significant difference among teachers with different age groups i.e. below 30 years, 30-45 years, 46 years and above. Further, it also revealed that no significant difference in occupational stress of teachers working in different regions (i.e. Telangana, Andhra and Rayalaseema).