Religion plays a very vital role in shaping human nature and human society. In the Millennia of human existence, religion has contributed variously to develop society, and also to mar its progress and mutual co-existence. Apart from Judaism, Buddhism, Hinduism, etc., there are also Christianity, Islam, and African Traditional Religion, especially within the African context. In this paper particularly, there is an attempt to examine the contact between Islam and Christianity, especially as they encountered Colonial Administration in the period before political independence. The inter-play between these religions and politics led to mutual suspicions and sometimes to decisions that eventually sowed the seed of mutual hatred, which still lingers so many years after the end of colonialism. The paper advocates a radical change of mind to embrace mutual co-existence.