Indian pharmaceutical industry has played a key role in promoting and sustaining development in the vital field of medicines. It ranks very high in the third world, in terms of technology, quality and range of medicines manufactured. The objective of the present study is to analyze the profitability and solvency performance of select pharmaceutical companies in India. The period of the study is from 2005- 2006 to 2014- 2015. The major finding of study indicates that Short term solvency ratios, like current ratio and liquid ratio are satisfactory only in the Sun pharmacy, the Dr Reddy, the Glenmark, the Arobindo pharmacy during the study period these companies able to meet short term financial obligations. The Lupin pharmacy, the Cipla pharmacy, the Torrent pharmacy, the Divis pharmacy, the Gloxo smith cline, the Cdilla should pay more attention to improve their current and liquid assets.