The study investigated job enrichment as predictor of work performance of Heads of Departments of Federal Universities in South-South Zone, Nigeria. One research question was answered and one null hypothesis was also tested at 0.05 alpha level. The study adopted a correlation design. The population for the study was 378 HoDs in 378 Departments in six Federal Universities in South-South, Nigeria. The sample size was 310 HoDs representing 82.01% of the population. Two self-designed instruments titled “Job Enrichment Scale” (JES) and “Work Performance Scale” (WPS) were used for data collection. Face and content validities were ensured by experts in Measurement and Evaluation in the Department of Psychology, Guidance and Counseling. Multiple and simple regression analysis were used to answer the research question while ANOVA and t-test associated with multiple and simple regression were used to test the null hypothesis at 0.05. It was found among others that Job enrichment (work meaningfulness, sense of responsibility and knowledge of result) significantly jointly predicted work performance among administrative staff of federal Universities in South-South Zone. It was recommended that controlled school climate should be encouraged in the Universities by the principal officers of the University. Again, the administrative staff should value and approach their job with achievement drive in order to effectively make use of their multiple skills.